Florence, 1494: Lisa Gherardini and Giuliano from the powerful Medici dynasty are secretly lovers. When the Medici are driven out of the city, Lisa's father forces the young woman to marry the much older silk merchant Francesco del Giocondo. But her heart is set on her lover.
Venice, 1495: Leonardo da Vinci is the most famous artist of his time. When Giuliano de' Medici asks him to paint a portrait of Lisa in order to send news to his beloved, Leonardo takes the risky gamble. As a result, Lisa is not only caught up in a dangerous conspiracy - her heart is also put to a severe test.